as you know there are many different serotonin receptor subtypes – have you considered the potential role of specific subtypes in your studies?
Thank you for your question! Yes, we are interested in 5-HT2a, 5-HT2c as these seem to be the biggest modulators of these compounds’ effects. Head twitch response is a really cool assay because it is behaviorally specific to the psychedelic effects of the 5-HT2a receptors. So when other agonists of the 5-HT2a receptor bind, like Lisuride(anti-parkison drug specific for 5-HT2a/c), it does not produce head twitch like psychedelic compounds. We want to in the future use tools like biosensors and optogenetics to further dissect how exactly these effects come about.
excellent! thank you
one more question
you did not indicate on your poster the level of significance for your findings – what statistical test did you use to analyze your data? or, did you feel that your n was too small to do a proper analysis?
We felt the sample size was too small to do a proper analysis. We are currently in the process of increasing sample sizes to make sure the results we are seeing are representative. We are hoping that increasing the sample size will decrease our variability and really highlight the effects.
OK – thanks