Remarkable study. How would this be followed up? Do you have access to a blood flow meter? You might try that out.
Thank you. The next steps would be to trial in other neurologic conditions, or to perform formal studies in the MS population. Particularly with more specific measures of muscle hypertrophy, functional performance, and long term effects.
So cool. What do you think the mechanism is for the improvement?
There have been several observations and theories. First, by decreasing available oxygen, type I muscle fibers are less active which allows type II fibers to be more heavily recruited and promote hypertrophy. There have also been some links to increases in growth hormones.
Really nice, Lauren. Need a giant Apple Watch type device for people to wear to monitor the blood flow and oxygenation. How widely available is the system – is it something affordable for rural areas?
Karen, the devices are affordable in that a rural therapy clinic could manage the cost. It isn’t a massive investment like some of the other neurorehab technologies. I was actually thinking it would be very interested to study blood flow restriction training in animal models post stroke. We could do high-intensity training +/- BFR and track biomarkers, motor function, etc.