You should chat with Nathan Glassy, he had the MEG poster on movement initiation in PD. His findings are restricted to cortex but there are some similarities.
I’ll take another look at his poster. Thanks for the suggestion!
This is an interesting study. I’m particularly interested in the decreased activity you observed in the anterior cingulate cortex and insula. Those areas play a role in decision making, attention processing, working memory, and error processing. So it makes sense that the PD group had problems with cognitive switching.
We also found that interesting. It is especially curious when you consider that areas involved in motor planning (rIFG and BA 4/6) showed higher activity during motor switching, which we could interpret as a compensation effect. During cognitive switching, however, the neural correlates showed decreased activity, and there was no clear sign of a compensatory increase in activity.
Your study is also interesting because you found increased activity in frontal regions suggesting that executive functions may be increased to make up for impaired information processing in the insula and ACC.
Do you have any followup studies planned? Any interest in looking at differences in functional connectivity between salience and executive control networks?
We are still finalizing the current study, but observing potential differences between salience and executive control networks is an interesting topic that we can consider for the future!